Immunomodulation of the prostate tumor microenvironment following inorganic Arsenic exposure

ABSTRACT: The tumor microenvironment shapes how prostate cancer (PCa) progresses through stromal-immune interactions. We investigated how adipose-derived mesenchymal/stromal cells (ASC) and chronic inorganic arsenic (iAs) exposure jointly influence PCa by using a Ras-driven murine model. ASC-conditioned media enhanced TC2Ras viability, while iAs reversed this effect. In vivo, ASC+iAs tumors showed increased weight, altered immune infiltration, and transcriptomic remodeling, including a sustained IFN-IRF1 axis and immune checkpoint upregulation. ASC-iAs crosstalk promotes immune tolerance, revealing mechanisms by which environmental toxicants modulate cancer immunity.

ORGANISM(S): Mus musculus

PROVIDER: GSE317208 | GEO | 2026/08/12

REPOSITORIES: GEO