Distinct Immune Signatures of Steroid Responsiveness in Childhood Nephrotic Syndrome

ABSTRACT: Idiopathic nephrotic syndrome (INS) is the most common primary glomerular disorder in children, yet the immunopathogenesis underlying steroid responsiveness remains incompletely understood. Here, we applied single-cell RNA sequencing to peripheral blood mononuclear cells obtained from three treatment-naïve children with steroid-sensitive nephrotic syndrome (SSNS) and one child with secondary steroid-resistant nephrotic syndrome (SRNS) at first relapse, all prior to immunosuppressive therapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE317299 | GEO | 2026/07/01

REPOSITORIES: GEO