Single-cell multiomics reveals naïve CD4⁺ T-cell dysregulation in treatment refractory rheumatoid arthritis

ABSTRACT: Here we determine single-nuclei transcriptional and chromatin landscapes using 10x Genomics Epi Multiome assay on primary CD4+ T-cells isolated from treatment-naïve early RA and refractory (defined as per EULAR definition of difficult-to-treat RA) RA patients. This approach enabled construction of an integrated map of subset-specific immunopathology, comparing rRA with eRA - two opposing ends of the RA disease continuum - to uncover mechanisms underlying treatment refractory disease and inform future therapeutic strategies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE317456 | GEO | 2026/09/14

REPOSITORIES: GEO