GPR56 as a Key Modulator of the Androgen-Responsive Transcriptome in Prostate Cancer Cells

ABSTRACT: To investigate the role of GPR56 in androgen-mediated gene regulation, RNA sequencing was performed in LNCaP (prostate cancer cells) wild-type or GPR56-knockdown (LNCaP cells transfected with GPR56 siRNA, GPR56-KD), following testosterone stimulation. Transcriptomic analysis revealed extensive androgen-responsive gene expression in LNCaP-WT cells, including established androgen target genes, which was markedly reduced upon GPR56 knockdown. These findings suggest that GPR56 is required for optimal androgen response of androgen-dependent transcriptome in prostate cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE317911 | GEO | 2026/04/12

REPOSITORIES: GEO