Fragmentation through cell-cell adhesion maintains senescent cell viability but promotes debris deposition

ABSTRACT: We identified that senescent cells dispose of large fragments of themselves through cell-to-cell adhesion, which we term senescent-cell adhesion fragments (SCAFs). Dynamic analyses show that SCAFs ultimately rupture, releasing a complex proteome including damage-associated molecular patterns (DAMPs) and proteins linked to neurodegenerative disease. Functionally, SCAFs activate wound-healing and cancer-related programs, promoting migration and invasion.

ORGANISM(S): Homo sapiens

PROVIDER: GSE317982 | GEO | 2026/02/12

REPOSITORIES: GEO