GDF15 impacts chronic kidney disease and associated cachexia through distinct mechanisms

ABSTRACT: Chronic kidney disease (CKD) is frequently accompanied by cachexia and substantial metabolic alterations, including anorexia, muscle/fat wasting, and inflammation, which collectively contribute topoor clinical outcomes.However, the underlying molecular mechanisms remain poorly understood. This study demonstrates that growth differentiation factor 15 (GDF15) plays a pivotal role in CKD-associated cachexia and molecular changes.

ORGANISM(S): Mus musculus

PROVIDER: GSE318188 | GEO | 2026/09/10

REPOSITORIES: GEO