The E-cadherin-Wnt-mir-994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

ABSTRACT: E-cadherin is encoded by the shg gene and is also expressed in Drosophila ovarian IGS cells. Its knockdown leads to a reduction in GSCs. To investigate the downstream molecular mechanisms and changes in gene expression, we labeled IGS cells with GFP, sorted GFP-positive cells one week after shg knockdown, and performed RNA sequencing. Finally, differential gene expression analysis along with GO and KEGG analyses were conducted.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE318190 | GEO | 2026/07/08

REPOSITORIES: GEO