Transcriptomics

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RNA-seq profiling of post-hypoxic head and neck cancer cell lines


ABSTRACT: Hypoxia is an important cause of radiotherapy resistance in head and neck squamous cell carcinoma (HNSCC). To investigate the transcriptional expression associated with post-hypoxic survival, we performed RNA-seq profiling of HPV-negative (FADU) and HPV-positive (SCC154) hypoxia-fate-mapped cell lines, hereafter called FADU-hfm and SCC154-hfm. Non-hypoxic (DsRed-positive) and post-hypoxic (GFP-positive) cells were sorted from 3D hfm-spheroids using fluorescence-activated cell sorting (FACS) and analyzed under normoxic conditions. The resulting dataset provides gene expression profiles of non-hypoxic and post-hypoxic cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE319374 | GEO | 2026/07/01

REPOSITORIES: GEO

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