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Drug-seq analysis of adult T-cell leukemia cells treated with fluorouracil and bleomycin

ABSTRACT: Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy that develops in a subset of individuals infected with human T-lymphotropic virus type 1 (HTLV-1) and is characterized by marked chemoresistance and frequent relapse. HTLV-1 preferentially infects CD4⁺ T cells, which constitute the main malignant population in ATL. We evaluated transcriptomic perturbations in CD4⁺ T cells from five ATL patients, three healthy donors, and two ATL cell lines following 48-hour treatment with the chemotherapeutic agents fluorouracil and bleomycin sulfate.

ORGANISM(S): Homo sapiens

PROVIDER: GSE319793 | GEO | 2026/09/09

REPOSITORIES: GEO

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