Hydroxychloroquine Alleviates Cyclophosphamide-Induced Premature Ovarian Failure by Attenuating Granulosa Cell Senescence and Modulating the mtDNA-cGAS Pathway

ABSTRACT: Cyclophosphamide (CTX) is a first-line chemotherapeutic agent for various cancers but is associated with a significant risk of ovarian dysfunction, which may even progress to premature ovarian failure (POF). Granulosa cell senescence is a key phenotypic manifestation of this process. Hydroxychloroquine (HCQ) exerts anti-senescence effects in age-related diseases; however, its efficacy in preventing CTX-induced ovarian damage remains elusive. We aimed to verify the protective effect of HCQ using a CTX-induced POF mouse model.

ORGANISM(S): Mus musculus

PROVIDER: GSE320421 | GEO | 2026/05/15

REPOSITORIES: GEO