Spatial transcriptomics dissects mechanism of action of the PD-1 targeted IL15-mutein in B16-F10-OVA tumor-bearing mice

ABSTRACT: KD050 is an anti-PD-1/IL-15 bi-functional antibody with strong PD-1 antagonist function, but lower lymphocyte stimulation enabled by a novel mutation on the IL-15. Here, we spatially characterized at RNA level the effect of mKD050 surrogate I in B16-OVA (melanoma) mouse model, in comparison with anti-mPD1 and mouse non-targetKD050 (mntKD050).

ORGANISM(S): Mus musculus

PROVIDER: GSE324814 | GEO | 2026/04/20

REPOSITORIES: GEO