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The immune response to a biodegradable polymer and corresponding collagen regeneration

ABSTRACT: In this study, we used RNA sequencing to investigate the molecular mechanisms underlying site-specific tissue regeneration induced by an injectable thermosensitive PLGA-PEG-PLGA hydrogel (T-gel) in rats. We compared the transcriptomic profiles of skin tissue following intradermal or subcutaneous injection of T-gel, with saline injections at corresponding sites as controls. This is evidenced by a greater number of differentially expressed genes and a significant enrichment of extracellular matrix organization and collagen biosynthesis pathways in the intradermal group compared to the subcutaneous group.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE325546 | GEO | 2026/04/22

REPOSITORIES: GEO

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The immune response to a biodegradable polymer and corresponding collagen regeneration

Project description:The immune response to a biodegradable polymer and corresponding collagen regeneration

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Effect of Intradermal Immunotherapy (IDIT) injections on gene expression profiles of activated T cells derived from skin biopsy explants

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A Biodegradable Piezoelectric Vertebral Implant for Programmable Electro-neuromodulation in Spinal Cord Injury

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The transcriptomic profile of peripheral blood nuclear cells in dogs with atopic dermatitis before and after 6 months allergen-specific immunotherapy.

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