ONX-0914 Ameliorates Hepatic Steatosis in MASLD by Stabilizing HDAC2 and Inhibiting SREBP1 Acetylation via PSMB8 Inhibition

ABSTRACT: To investigate the mechanism by which ONX‑0914 ameliorates MASLD, HFD‑fed mice were randomized to receive the selective PSMB8 inhibitor ONX‑0914 (10 mg/kg in 10% captisol, s.c., every other day) or vehicle control for an additional 6 weeks while remaining on the HFD. At the experimental endpoint, liver tissues were collected for RNA sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE326369 | GEO | 2026/04/02

REPOSITORIES: GEO