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Integrative transcriptomic analysis reveals Cytip as a novel pro-inflammatory factor which interacting with Lrrfip2 in microglia following

ABSTRACT: In this study, we sought to elucidate the transcriptional landscape of microglia during the acute phase of cerebral I/R injury. By integrating transcriptomic data from an in vivo mouse model of middle cerebral artery occlusion/reperfusion (MCAO/R), with in vitro bulk RNA sequencing of Bv2 microglia subjected to oxygen-glucose deprivation/reperfusion (OGD/R), we identified Cytip (Cytohesin Interacting Protein) as significantly upregulated. Our results demonstrated that CYTIP expression peaked 24 h post-reperfusion and its knockdown markedly attenuated neuroinflammation.

ORGANISM(S): Mus musculus

PROVIDER: GSE326830 | GEO | 2026/07/14

REPOSITORIES: GEO

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