A High Dimensionality Approach Reveals Immunopathogenic Responses Driving Severe Pediatric Acute Respiratory Distress Syndrome

ABSTRACT: Mechanisms underlying paediatric acute respiratory distress syndrome (PARDS) remain poorly understood, limiting advances in diagnosis and treatment. To address this gap, we adopted a high-dimensional multi-omics approach to better understand immune dysregulation in PARDS, aiming to identify distinct pathogenic pathways. We show that severe PARDS is marked by interferon-driven immune dysregulation, with pulmonary T cells and myeloid cells exhibiting strong interferon responses and suppressed IL-1 pathways, resulting in impaired immune cell function and reduced IL-1α/β levels.

ORGANISM(S): Homo sapiens

PROVIDER: GSE327171 | GEO | 2026/05/12

REPOSITORIES: GEO