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Single-cell transcriptomic profiling unveils tumor-mediated reprogramming of neutrophils and their unique vulnerability that inhibits metastasis

ABSTRACT: We performed single cell RNA sequencing (scRNAseq) with the 10x Genomics platform to study how neutrophils are reprogrammed during breast tumorigenesis. Neutrophils acquire a pro-metastatic phenotype induced by signals eminating from the tumor. This comprehensive scRNAseq study assessed neutrophils from various tissues in naive and tumor-bearing MMTV-PyMT mice to uncover how neutrophils are transcriptionally modified. We found that neutrophils are reprogrammed similarly amongst tissues in tumor-bearing mice, and that G-CSF is the main driver of this.

ORGANISM(S): Mus musculus

PROVIDER: GSE327176 | GEO | 2026/07/17

REPOSITORIES: GEO

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