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CHCHD10 alleviates Alzheimer’s Disease Pathogenesis by Modulating Epigenetic Landscape in Directly Reprogrammed Neurons

ABSTRACT: Alzheimer’s disease (AD) is associated with widespread epigenetic alterations, including changes in DNA methylation. CHCHD10, a mitochondrial intermembrane space protein, has been implicated in mitochondrial function and neurodegeneration, but its role in epigenetic regulation remains unclear. In this study, we performed genome-wide DNA methylation profiling in fibroblast-derived induced neurons from cognitively normal controls (NC) and AD patients, with and without CHCHD10 overexpression. We identified disease-associated differentially methylated regions (DMRs) and evaluated the extent to which CHCHD10 restoration modulates these epigenetic signatures. This dataset provides a resource for understanding mitochondrial-epigenetic interactions in AD.

ORGANISM(S): Homo sapiens

PROVIDER: GSE328184 | GEO | 2026/06/29

REPOSITORIES: GEO

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