Smad4/SKI/SKIL-mediated chromatin accessibility changes during the CD8 T cell response

ABSTRACT: Transforming growth factor-β (TGF-β) is an immunosuppressive cytokine that regulates both innate and adaptive immune responses. Earlier studies have shown that TGF-β plays a role in promoting T cell exhaustion during the later stages of chronic viral infection. In this dataset we examined the global chromatin accessibility changes in CD8 T cells that are dependent on SMAD4. Our findings documenting the striking requirement for Smad4-SKI-SKIL mediated restraint of TGF-β-associated program during the effector phase of the CD8 T cell response have implications for developing immunotherapeutic approaches against chronic viral infections and cancer.

ORGANISM(S): Mus musculus

PROVIDER: GSE328742 | GEO | 2026/09/03

REPOSITORIES: GEO