Transcriptomic profiling of BAZ1A-AS1 and BAZ1A knockdown in human vascular smooth muscle cells and rhabdomyoblasts

ABSTRACT: BAZ1A-AS1 is a novel human-specific long non-coding RNA upregulated during neointima proliferation in human saphenous veins. To elucidate the transcriptional programs regulated by BAZ1A-AS1 and its cis-regulatory gene BAZ1A, we performed bulk RNA-seq on human saphenous vein smooth muscle cells (HSVSMCs) with BAZ1A-AS1 knockdown (LNA gapmeR ASO) and rhabdomyoblast (RD) cells with BAZ1A knockdown (siRNA) under UV exposure. Differential expression analysis revealed convergent suppression of proliferative, inflammatory, and stress-response transcriptional programs across both knockdowns, supporting a shared regulatory axis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE329766 | GEO | 2026/07/01

REPOSITORIES: GEO