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EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy

ABSTRACT: EIF1, an RNA-binding protein implicated in multiple diseases, remains poorly characterized in diabetic retinopathy (DR). To investigate its role in DR, human retinal pigment epithelial cells (ARPE-19) were exposed to 50 mM glucose to model the condition. Under hyperglycemic conditions, EIF1 was knocked down using siRNA, followed by transcriptome sequencing (RNA-seq) to profile differentially expressed genes (DEGs) and alternative splicing events (ASEs).

ORGANISM(S): Homo sapiens

PROVIDER: GSE334496 | GEO | 2026/06/08

REPOSITORIES: GEO

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