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Genome-wide DNA Methylation Profiling in Postpartum Depression: A Longitudinal Whole-Blood Study

ABSTRACT: This dataset contains genome-wide DNA methylation data derived from whole human blood samples collected from postpartum women enrolled in a longitudinal cohort study (2018–2023, N = 827). Blood samples were drawn within 6 days of delivery (t0) and at 12 weeks postpartum (t4). Participants were assessed longitudinally for postnatal depression (EPDS), perceived stress (PSS-10), and mother-infant attachment (MPAS). A subset of N = 247 participants with complete blood sampling was used for methylation analysis; mothers with the most severe depressive symptoms (PPD group, n = 17, DSM-5 confirmed) were compared to a euthymic healthy control group (HC, n = 24). Genome-wide methylation profiling was performed using the Illumina Infinium Human MethylationEPICv2 BeadChip. Differential methylation analysis was conducted using the ChAMP package (BMIQ normalization, limma-based DMP calling). The goal of this study is to identify epigenetic signatures associated with postpartum depression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE335141 | GEO | 2026/09/22

REPOSITORIES: GEO

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