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Effect of curing the phi027 prophage for gene expresson in Clostridioides difficile clinical isolate 500/12

ABSTRACT: Clostridioides difficile is a clinically important nosocomial pathogen whose virulence is primarily associated with toxin production and can be influenced by prophage carriage. In this study, we investigated the molecular basis of phi027-dependent phenotypic differences previously observed between the clinical RT176 strain 500/12 and its prophage-free derivative CKH08. Comparative transcriptomic analysis revealed that loss of phi027 was associated with reduced expression of the sinR/R' operon, downregulation of multiple flagellar biosynthesis genes.

ORGANISM(S): Clostridioides difficile

PROVIDER: GSE336602 | GEO | 2026/07/01

REPOSITORIES: GEO

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