Effect of peripheral kappa-opioid receptor agonists on murine T cells

ABSTRACT: This study investigated the transcriptional responses of murine T cell subsets to treatment with novel peripherally restricted, perhydroquinoxaline-derived kappa opioid receptor (KOR) agonists. We sorted and polarized primary murine CD4+ and CD8+ T cells towards Th1, Th17, Treg and CD8+ T cells and stimulated them with novel KOR agonists or vehicle control (DMSO). RNA sequencing was performed to assess gene expression changes associated with KOR activation across distinct T cell subsets.

ORGANISM(S): Mus musculus

PROVIDER: GSE336897 | GEO | 2026/07/03

REPOSITORIES: GEO