Whole-transcriptome sequencing of NT2.5, NT2.5LM, and NT2.5LV: a HER2-positive murine breast cancer cell line series with lung- and liver-preferential metastasis

ABSTRACT: The NT2.5 cell line and its lung-preferential (NT2.5LM) and liver-preferential (NT2.5LV) metastatic derivatives constitute an isogenic HER2-positive murine breast cancer model derived from neu-N transgenic FVB/N mice. To define the transcriptional programs associated with organ-preferential metastatic colonization, we performed bulk poly(A) RNA-sequencing on the three cell lines grown in vitro. Differential expression analysis identified divergent, organ-correlated transcriptional programs distinguishing the lung- and liver-preferential derivatives on a conserved genomic background. These data accompany the whole-genome sequencing of the same cell line series deposited under the same BioProject.

ORGANISM(S): Mus musculus

PROVIDER: GSE336999 | GEO | 2026/08/08

REPOSITORIES: GEO