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Genome-wide RRBS methylation profiling identifies NLRP7 promoter hypermethylation associated with disease severity in epidermolysis bullosa simplex

ABSTRACT: Reduced representation bisulfite sequencing (RRBS) was performed to investigate DNA methylation profiles in patients with epidermolysis bullosa (EB) exhibiting variable disease severity. Differential methylation analysis identified a differentially methylated region within the NLRP7 promoter and first exon. The dataset provides genome-wide DNA methylation profiles generated from peripheral blood leukocyte DNA and is intended to facilitate studies of epigenetic mechanisms associated with EBS disease severity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE338068 | GEO | 2026/07/10

REPOSITORIES: GEO

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Genome-wide RRBS methylation profiling identifies NLRP7 promoter hypermethylation associated with disease severity in epidermolysis bullosa simplex

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