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Chip seq data of transcription factor ELF-1 in mouse BMDM derived macrophages.

ABSTRACT: Acute kidney injury (AKI) is an unavoidable complication following renal transplantation and a critical determinant of patient prognosis. M1-polarized macrophages are known to exacerbate the progression of AKI. Preliminary clinical data reveal a positive correlation between the expression level of E74-like ETS transcription factor 1 (ELF-1) in macrophages from post-transplant patients and the levels of pro-inflammatory cytokines. However, the role of ELF-1 in M1 macrophage polarization and the pathogenesis of AKI remains unclear. In this study, we aim to investigate the role of ELF-1 in M1 macrophage polarization and AKI pathogenesis by employing ELF-1-deficient murine macrophages and performing ChIP-seq to identify downstream genes regulated by ELF-1.

ORGANISM(S): Mus musculus

PROVIDER: GSE338150 | GEO | 2026/07/09

REPOSITORIES: GEO

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