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Spatially Resolved Cell-Cell Communication in Small Cell Lung Cancer Reveals Macrophage-Driven Immune Evasion Programs

ABSTRACT: Small cell lung cancer (SCLC) exhibits poor responses to immunotherapy despite abundant immune infiltration. We performed single-cell spatial transcriptomic profiling of more than 2.5 million cells from six surgically resected limited-stage SCLC tumors using the 10x Genomics Xenium In Situ platform (5K Human Pan Tissue & Pathways Panel). Spatially resolved cell-cell communication analysis identified macrophages as the dominant communicating immune population and revealed distinct spatial macrophage states associated with differential T-cell phenotypes and immune evasion programs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE343063 | GEO | 2026/08/18

REPOSITORIES: GEO

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