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Effect of imatinib on cisplatin-induced nephrotoxicity in mice

ABSTRACT: Cisplatin is a chemotherapeutic agent that induces proximal tubule injury in the kidneys. We aimed at exploring the effect of imatinib, a Tyrosine Kinase Inhibitor (THI), on the entry of cisplatin in proximal tubular cells and on cisplatin-induced DNA damage. RNA sequencing was performed in whole kidneys of mice (control groupe, n=4, 20mg/kg cisplatin-treated mice, n=4, 20mg/kg cisplatin + 150mg/kg imatinib-treated mice, n=4), which were collected 3 days after cisplatin intraperitoneal injection. In the cisplatin + imatinib group, imatinib was injected the day before cisplatin injection, and every day until the mice were euthanized.

ORGANISM(S): Mus musculus

PROVIDER: GSE343588 | GEO | 2026/08/17

REPOSITORIES: GEO

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