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Gene expression analysis of HSD17B4 knock-out breast cancer cells

ABSTRACT: HER2-positive breast cancer has a high chance of achieving pathological complete response when HSD17B4, responsible for peroxisomal β-oxidation of very long-chain fatty acids and estradiol, is methylation-silenced. Here, we aimed to identify the underlying molecular mechanism. We conducted RNA-seq analysis and Gene Set Enrichment Analysis to make an unbiased search for genes driven by HSD17B4 KO. Analysis of the pathways upregulated by HSD17B4 depletion revealed a gene network associated with oxidative phosphorylation, using the KEGG database, and that associated with the mitochondrial respiratory chain, using the GOBP terms.

ORGANISM(S): Homo sapiens

PROVIDER: GSE344585 | GEO | 2026/09/01

REPOSITORIES: GEO

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