Effect of depletion of Grina on gene expression during HSV-1 infection of BMDMs

ABSTRACT: To investigate the role of Grina in HSV-1-induced signaling pathways, we isolated total RNA from Grina-knockout (Grina-KO) BMDMs and their wild-type (WT) controls, with or without HSV-1 infection. Bone marrow-derived macrophages were generated from Grina-floxed (Grina-fl/fl) and Lyz2-Cre-mediated Grina-KO mice, and were mock-infected or infected with HSV-1 (MOI = 1) for 4 hours. Total RNA was extracted from four biological replicates per condition, representing four experimental groups: WT mock, WT HSV-1, KO mock, and KO HSV-1. This dataset enables comprehensive identification of Grina-dependent transcriptional responses during HSV-1 infection, providing insights into the crosstalk between Grina-mediated signaling and antiviral innate immunity.

ORGANISM(S): Mus musculus

PROVIDER: GSE345297 | GEO | 2026/09/01

REPOSITORIES: GEO