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Developmental Arrest Associated with Altered Cerebellar Metabolism in Sudden Infant Death Syndrome

ABSTRACT: Sudden infant death syndrome (SIDS) may involve impaired cerebellar contributions to autonomic and arousal responses during hypoxic stress. We performed bulk RNA sequencing of flash-frozen postmortem human cerebellar cortex from SIDS infants and age-matched non-SIDS controls to define transcriptional alterations associated with SIDS. Differential-expression and pathway-enrichment analyses were used to evaluate neuroinflammatory, neurotransmitter, and metabolic programs, and transcriptomic findings were compared at the pathway level with independently generated targeted metabolomics and quantitative histology data.

ORGANISM(S): Homo sapiens

PROVIDER: GSE345466 | GEO | 2026/08/30

REPOSITORIES: GEO

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