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Microglial dysregulation promotes aberrant synaptic engulfment and CXCL10-associated CD8⁺ T-cell accumulation in CMT2A mice

ABSTRACT: Charcot–Marie–Tooth disease type 2A (CMT2A), caused by pathogenic variants in MFN2, is primarily recognized as a peripheral axonopathy. Depression and psychological distress have also been reported in patients with CMT, but it remains unclear whether MFN2 mutations engage central neuroimmune mechanisms that affect behavior.

ORGANISM(S): Mus musculus

PROVIDER: GSE345566 | GEO | 2026/09/04

REPOSITORIES: GEO

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