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Inducible endothelial Plvap knockout RPE-choroid tissue sinlge cell transcriptomic analysis

ABSTRACT: This single-cell RNA-sequencing dataset was generated to investigate cellular and transcriptional changes following endothelial PLVAP loss in the adult mouse retina–choroid. Control and inducible endothelial-specific PLVAP knockout (PLVAPiECKO) mice were analyzed 10 days after PLVAP deletion. Single-cell transcriptomic profiling was used to characterize major retinal and choroidal cell populations and to examine PLVAP-loss-associated changes in choriocapillaris endothelial cells, retinal pigment epithelial cells, and photoreceptors. The dataset provides a cellular framework for understanding how disruption of PLVAP-dependent endothelial fenestration affects vascular–tissue exchange and metabolic homeostasis in the outer retina.

ORGANISM(S): Mus musculus

PROVIDER: GSE345745 | GEO | 2026/09/06

REPOSITORIES: GEO

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Inducible endothelial Plvap knockout RPE-choroid tissue sinlge cell transcriptomic analysis

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