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CPEB1 Overexpression Rewires Alternative Splicing in T98G Cells: A Resource for Alzheimer's Disease Research

ABSTRACT: Alzheimer's disease is a multifactorial neurodegenerative disorder with incompletely understood molecular mechanisms. Cytoplasmic polyadenylation element-binding protein 1 (CPEB1) is an RNA-binding protein implicated in post-transcriptional regulation and synaptic function, but its regulatory network in human neural cells remains underexplored. In this study, bulk RNA sequencing was performed on T98G human glioblastoma cells transfected with a CPEB1 overexpression construct or the corresponding empty-vector control. Differential gene expression and alternative splicing analyses were performed using DESeq2 and the ABLas pipeline, respectively. Functional enrichment analysis and comparison with Alzheimer's disease-associated gene sets were used to identify candidate CPEB1-regulated genes and splicing events relevant to Alzheimer's disease research.

ORGANISM(S): Homo sapiens

PROVIDER: GSE346108 | GEO | 2026/09/06

REPOSITORIES: GEO

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CPEB1 Overexpression Rewires Alternative Splicing in T98G Cells: A Resource for Alzheimer's Disease Research

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