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Transcriptomic profiling of brain regions and primary fibroblasts from BRD1 haploinsufficient Göttingen minipigs

ABSTRACT: BRD1 is a chromatin-associated transcriptional regulator implicated in psychiatric disorders. To investigate the transcriptional consequences of BRD1 haploinsufficiency in a translational large-animal model, we performed RNA sequencing of multiple brain regions and primary fibroblasts from BRD1 haploinsufficient (BRD1+/-) and wild-type Göttingen minipigs. The study identifies tissue- and brain region-specific transcriptional alterations associated with reduced BRD1 function and forms part of a broader multimodal characterization of the neurodevelopmental and systemic consequences of BRD1 haploinsufficiency.

ORGANISM(S): Sus scrofa

PROVIDER: GSE346909 | GEO | 2026/09/15

REPOSITORIES: GEO

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