Dynamic Supramolecular Hydrogel Reprogram Probiotic Metabolism and Enhance Therapeutic Efficacy in Periodontitis

ABSTRACT: Hydrogel network dynamics can influence the biological function of encapsulated probiotics. We performed RNA sequencing to compare the transcriptional profiles of Lacticaseibacillus paracasei encapsulated in dynamic supramolecular (Lp@PP) and static covalently crosslinked (Lp@BM) hydrogels. Our analysis revealed distinct growth-associated and stress-adaptive transcriptional programs in Lp@PP and Lp@BM, respectively.

ORGANISM(S): Lacticaseibacillus paracasei

PROVIDER: GSE346990 | GEO | 2026/09/20

REPOSITORIES: GEO