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Transcriptomic profiling of CT26 tumor-bearing mice treated with novel HDAC inhibitor GNTbm-38

ABSTRACT: Histone deacetylase inhibitors (HDACis) represent a promising therapeutic strategy in cancer treatment. In this study, we evaluated the therapeutic efficacy and molecular mechanisms of GNTbm-38, a novel HDAC inhibitor, using a syngeneic CT26 colon carcinoma tumor-bearing mouse model. BALB/c mice bearing subcutaneous CT26 tumors were treated with vehicle control or GNTbm-38. Bulk RNA-sequencing was performed on tumor tissues to characterize transcriptomic alterations induced by GNTbm-38. This dataset provides comprehensive gene expression profiles to elucidate the antitumor and immunomodulatory pathways regulated by GNTbm-38 in colorectal cancer.

ORGANISM(S): Mus musculus

PROVIDER: GSE347712 | GEO | 2026/09/17

REPOSITORIES: GEO

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