Single-cell ATAC-seq profiling of ARID1A-loss-associated chromatin accessibility heterogeneity in pancreatic cancer cells

ABSTRACT: This Series contains single-cell ATAC-seq datasets from clone-resolved and pooled perturbation experiments examining how ARID1A and other epigenetic modifiers influence chromatin-accessibility heterogeneity in pancreatic ductal adenocarcinoma cells. The datasets include the main 28-clone BxPC3 experiment, a large-scale pooled five-shRNA experiment, acute SMARCA4 degradation with AU-15330, and independent experiments in BxPC3, HPAC/HPAFII, SW1990, and SUIT-2 backgrounds. PseuMO-Tag lineage barcodes were used to connect single-cell chromatin profiles to clonal identity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE347847 | GEO | 2026/09/22

REPOSITORIES: GEO