Transcriptomics

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Expression data from mice peritoneal cells


ABSTRACT: Sodium methyldithiocarbamate (SMD) is one of the most abundantly used conventional pesticides in the U.S. At dosages relevant to occupational exposure, it causes major effects on the immune system in mice, including a decreased resistance to sepsis. This lab has identified some of the mechanisms of action of this compound and some of the immunological parameters affected, but the global effects have not previously been assessed. We used microarrays to analyze the effect of SMD on lipopolysaccharide-induced mediators important in innate immunity and inflammation and reveal a broad effect on expression of transcription factors involved in Toll-like Receptors 4 (TLR4) signaling.

ORGANISM(S): Mus musculus

PROVIDER: GSE42877 | GEO | 2012/12/13

SECONDARY ACCESSION(S): PRJNA183693

REPOSITORIES: GEO

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