Genomics

Dataset Information

43

ChIP-Seq experiments of KLF5, GATA4 and GATA6 in YCC3/AGS/KATOIII cell lines


ABSTRACT: Three transcription factors KLF5, GATA4 and GATA6 are recurrently amplified in multiple gastric cancer cohorts, representing one type of lineage-survival oncogenes in gastric cancer. ChIP-Seq analysis of these three factors in multiple cell lines revealed that significant number of genomic sites are co-occupied by KLF5 and GATA4 and/or GATA6. Integrative analysis of ChIP-Seq and gene expression identified several targets of the three transcription factors in both cell lines and primary tumors, including HNF4A. These results suggest that KLF5, GATA4 and GATA6 interact and co-operate to regulate HNF4A and other genes to promote tumorigenesis in gastric cancer. Overall design: ChIP-Seq experiments of KLF5, GATA4 and GATA6 were performed in three gastric cancer cell lines YCC3, AGS and KATOIII

INSTRUMENT(S): Illumina Genome Analyzer IIx (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: Niantao Deng  

PROVIDER: GSE51705 | GEO |

SECONDARY ACCESSION(S): PRJNA224585

REPOSITORIES: GEO

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