Transcriptomics,Genomics

Dataset Information

42

B. thetaiotaomicron harvested from cecum of P17 and P30 NMRI mice


ABSTRACT: Gnotobiotic NMRI mice were colonized at birth with B. thetaiotaomicron. Mice were sacrificed at P17 or P30, cecal contents were harvested and used for transcriptional profiling. Keywords: developmental timepoints, in vivo Overall design: Gnotobiotic NMRI mice were colonized at birth with B. thetaiotaomicron. Mice were sacrificed at P17 or P30, cecal contents were harvested and used for transcriptional profiling.

INSTRUMENT(S): bthetaa511044F

SUBMITTER: Magnus K Bjursell  

PROVIDER: GSE5278 | GEO | 2006-09-01

SECONDARY ACCESSION(S): PRJNA104309

REPOSITORIES: GEO

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Publications

Functional genomic and metabolic studies of the adaptations of a prominent adult human gut symbiont, Bacteroides thetaiotaomicron, to the suckling period.

Bjursell Magnus K MK   Martens Eric C EC   Gordon Jeffrey I JI  

The Journal of biological chemistry 20060912 47


The adult human gut microbiota is dominated by two divisions of Bacteria, the Bacteroidetes and the Firmicutes. Assembly of this community begins at birth through processes that remain largely undefined. In this report, we examine the adaptations of Bacteroides thetaiotaomicron, a prominent member of the adult distal intestinal microbiota, during the suckling and weaning periods. Germ-free NMRI mice were colonized at birth from their gnotobiotic mothers, who harbored this anaerobic Gram-negative  ...[more]

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