Transcriptomics,Genomics

Dataset Information

45

Gene Expression Profiling of Familial and Sporadic Cases of Interstitial Pneumonia


ABSTRACT: Rationale: Idiopathic interstitial pneumonia (IIP) and its’ familial variants are progressive and largely untreatable disorders with poorly understood molecular mechanisms. Both the genetics and the histologic type of IIP play a role in understanding the etiology and pathogenesis of interstitial lung disease, but transcriptional signatures of these subtypes are unknown. Objectives: To evaluate gene expression in the lung tissue from patients with usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP) that were either familial or non-familial in origin and compare them to gene expression from normal lung parenchyma. Methods: We profiled RNA from lungs of 16 patients with sporadic IIP, 10 with familial IIP, and 9 normal controls on a whole human genome oligonucleotide microarray. Results: Significant transcriptional differences exist in familial and sporadic IIPs. The genes distinguishing the genetic subtypes belong to the same functional categories as transcripts that distinguish IIP from normal samples. Relevant categories include chemokines and growth factors and their receptors, complement components, genes associated with cell proliferation and death, and genes in the Wnt pathway. Keywords: disease state analysis Overall design: 35 lung RNA samples were profiled against universal human RNA reference (Stratagene) in duplicate with Cy3 and Cy5 dyes swapped. 9 samples are normal lung tissue and 26 samples are subjects with idiopathic interstitial pneumonia (10 have familal form of the disease and 16 have sporadic IIP).

INSTRUMENT(S): NIH-NIEHS/Agilent Human Familial IIP 43K array

SUBMITTER: Ivana V Yang  

PROVIDER: GSE5774 | GEO | 2006-10-01

SECONDARY ACCESSION(S): PRJNA97121

REPOSITORIES: GEO

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Publications

Gene expression profiling of familial and sporadic interstitial pneumonia.

Yang Ivana V IV   Burch Lauranell H LH   Steele Mark P MP   Savov Jordan D JD   Hollingsworth John W JW   McElvania-Tekippe Erin E   Berman Katherine G KG   Speer Marcy C MC   Sporn Thomas A TA   Brown Kevin K KK   Schwarz Marvin I MI   Schwartz David A DA  

American journal of respiratory and critical care medicine 20060922 1


Idiopathic interstitial pneumonia (IIP) and its familial variants are progressive and largely untreatable disorders with poorly understood molecular mechanisms. Both the genetics and the histologic type of IIP play a role in the etiology and pathogenesis of interstitial lung disease, but transcriptional signatures of these subtypes are unknown.To evaluate gene expression in the lung tissue of patients with usual interstitial pneumonia or nonspecific interstitial pneumonia that was either familia  ...[more]

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