Genome-wide shRNA screen to identify cellular regulators of the maintenance of HIV-1 latency

ABSTRACT: Latent HIV-1 infection represents a barrier to virus eradication as latent HIV-1 is impervious to the effects of antiretroviral drugs and can avoid detection by the host immune system. Strategies to clear latent HIV-1 infection in patients have so far failed in clinical trials to increase the decay rate of the latent reservoir underscoring the need for continued study of HIV-1 latency. In this study, a genome-wide RNAi screen was performed to probe cellular factors involved in maintaining HIV-1 latency in HeLa cells latently infected with an HIV-1 reporter virus.

ORGANISM(S): Homo sapiens

PROVIDER: GSE59758 | GEO | 2016/07/14

SECONDARY ACCESSION(S): PRJNA256145

REPOSITORIES: GEO