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Expression of genes in E17 p57-/- and p57+/+ hepatic mesothelial and submesothelial cells

ABSTRACT: To analyze p57 function in mouse fetal liver, we surgically isolated mesothelial and submesothelial cells from E17 p57-/- and p57+/+ livers.

ORGANISM(S): Mus musculus

PROVIDER: GSE61010 | GEO | 2014/10/01

SECONDARY ACCESSION(S): PRJNA260070

REPOSITORIES: GEO

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Expression of genes in E17 p57-/- and p57+/+ hepatic mesothelial and submesothelial cells

Project description:To analyze p57 function in mouse fetal liver, we surgically isolated mesothelial and submesothelial cells from E17 p57-/- and p57+/+ livers. Compared gene expression in E17 p57-/- and p57+/+ hepatic mesothelial and submesothelial cells.

2014-10-01 | E-GEOD-61010 | biostudies-arrayexpress

Mus musculus

Project description:Expression of genes in E17 p57-/- and p57+/+ hepatic mesothelial and submesothelial cells

| PRJNA260070 | ENA

Expression data from fetal and adult mouse liver mesothelial cells

Project description:Characterization and Functional Analyses of Hepatic Mesothelial Cells in Mouse Liver Development. We used microarrays to detail the global programme of gene expression in mesothelial cells during mouse liver development. Mouse liver mesothelial cells were selected by a cell sorter at E12.5 and adult for RNA extraction and hybridization on Affymetrix microarrays. We obtained PCLP1+ cells and Mesothelin+ cells at each developmental stage in order to analyze expression profiles of mesothelial cells.

2009-11-09 | E-GEOD-18937 | biostudies-arrayexpress

Transcriptome of E17 wild-type and Myh10L458R/L458R mutant lungs

Project description:Transcriptomic analysis between E17 wild-type and Myh10L458R/L458R mutant lungs (left lobes)

2018-09-17 | GSE119399 | GEO

Identification of mesothelial-to-mesenchymal gene signature in ascitic fluid-isolated mesothelial cells through RNA-sequencing

Project description:RNA-sequencing analysis was carried out on ascetic fluid-isolated mesothelial cells from ovarian cancer patients compared to control human peritoneal mesothelial cells to identify a mesothelial-mesenchymal gene signature.

2017-03-01 | GSE84829 | GEO

Hepatic lipid metabolism in chicken lines divergently selected for abdominal fat content

Project description:We performed gene expression profiling on chicken livers at five important embryonic developmental stages (E7, E12, E14, E17 and E21), which were selected from chicken lines with significant differences in abdominal fat content. Each developmental stage had its unique gene expression pattern and stage-specific differentially expressed genes (DEGs). Furthermore, the three rapid growth periods (E12, E14 and E17) had similar expression patterns. Between the two broiler lines, E17 had the largest number of significantly differentially expressed genes (979), specifically enriched in fatty acid metabolism and biosynthesis, PPAR signaling and glycolysis pathways. Therefore, genome-wide gene expression recapitulated the developmental pattern of chicken embryos, and found the important molecular pathways for hepatic lipid metabolism.

2018-06-04 | GSE101182 | GEO

Placental and decidual timecourse samples normalized and modeled with an undissected e17 sample

Project description:We used full genome microarrays to profile the full lifetime of the mouse placenta from embryonic day 8.5 (e8.5), at the time of chorioallantoic fusion, until postnatal day 0 (P0). For these samples, at each stage the fetal placenta and maternal decidual tissues were dissected and profiled separately (See series 1). For this experiment (Series 2), placental and decidual timecourse samples were normalized and modeled with two undissected (including placental and decidual tissue) e17 placentas to allow for scaling of values for comparison to the undissected placenta samples used in the publicly available mouse GeneAtlas dataset Keywords: time course

2008-04-23 | GSE11222 | GEO

Gene expression profiles of Ccl21a+ and Rank+ E17 thymic epithelial cells

Project description:Gene expression profiles of Ccl21a+ and Rank+ E17 thymic epithelial cells (TECs) were compared using Ccl21a-tdTomato-KI Rank-Venus-Tg mice

2023-11-09 | GSE239913 | GEO

Single cell RNA-sequencing of murine endothelial and stromal populations at embryonic day 17 (E17)

Project description:The origin of bone marrow stromal cells (BMSCs) is not completely understood. We have identified a rare population of cells with a transcriptional profile consistent with endothelial to mesenchymal transition (Endo-MT) in human fetal development. Therefore, we hypothesized that Endo-MT contributes to bone marrow niche formation in mammals. Here, we sought to determine whether Endo-MT cells could be identified in murine bone marrow during embryonic development. We isolated bone marrow and collagenased bone fraction from long bones of 9 fetuses at embryonic day 17 (E17) and FACS purified endothelial cells and BMSCs for single cell RNA sequencing.

2021-01-21 | E-MTAB-9994 | biostudies-arrayexpress

Expression data from FedEV uptake mesothelial cells

Project description:Asbestos-associated diseases remain a social burden worldwide. Our previous studies identified asbestos-induced iron-rich milieu for mesothelial cells with ceaseless macrophage ferroptosis. However, molecular mechanisms how this mutagenic milieu influences mesothelial cells have not been elucidated yet. Here, we propose a novel mechanism that extracellular vesicles (EVs) mediate asbestos-associated mutagenic factors to mesothelial cells. In a mice model of intraperitoneal crocidolite injection, mutagenic milieu highly expressed CD63, an exosomal marker. We then used a CD63-GFP labeled THP-1 macrophage model exposed to crocidolite/iron, which generated EVs under ferroptotic process. We observed that MeT-5A mesothelial cells can receive and internalize these EVs. Furthermore, we comprehensively analyzed the ferroptosis-dependent EVs (FedEVs) for transported proteins and identified ferritin heavy/light chains as major proteins. Therefore, we inferred that FedEVs transport iron from ferroptotic macrophages to mesothelial cells. RNA sequencing revealed that the mesothelial cells receiving higher amounts of the FedEVs were mitotic, especially at the S and G2/M phases, by the use of Fucci mesothelial cells. Nuclear 8-hydroxy-2`-deoxyguanosine and γ-H2AX were significantly increased in the recipient mesothelial cells after exposure to FedEVs. Collectively, we here demonstrate a novel mechanism that FedEVs act as a key mutagenic mediator by transporting iron, which contribute to asbestos-induced mesothelial carcinogenesis.

2021-10-22 | GSE184368 | GEO

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