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Histone ChIP-chip of adult hippocampus tissue from fetal alcohol exposed mice

ABSTRACT: In this experiment, we exposed mice to ethanol injections on postnatal days 4 and 7. We then extracted whole-hippocampus on postnatal day 70. We performed two ChIP-chip experiments on all mice form the same tissue using antibodies against H3K4me3 and H3K27me3. We found alterations in both modifications at many sites, including CTCF motifs of protocadherin genes and imprinted loci. We also found many affect lipid metabolism pathways. Overall design: Comparision of neonatal ethanol-injected with saline injected C57BL/6J mouse hippocampus in adulthood (day 70)

INSTRUMENT(S): NimbleGen Mouse Deluxe Promoter Array [100718_MM9_Deluxe_Prom_ChIP_HX1]

SUBMITTER: Eric Jonathon Diehl  

PROVIDER: GSE61488 | GEO | 2014-09-18



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Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure.

Chater-Diehl Eric J EJ   Laufer Benjamin I BI   Castellani Christina A CA   Alberry Bonnie L BL   Singh Shiva M SM  

PloS one 20160502 5

The molecular basis of Fetal Alcohol Spectrum Disorders (FASD) is poorly understood; however, epigenetic and gene expression changes have been implicated. We have developed a mouse model of FASD characterized by learning and memory impairment and persistent gene expression changes. Epigenetic marks may maintain expression changes over a mouse's lifetime, an area few have explored. Here, mice were injected with saline or ethanol on postnatal days four and seven. At 70 days of age gene expression  ...[more]

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