Transcriptomics

Dataset Information

19

Oncogenic potential of RAS isoforms in melanocytes


ABSTRACT: We compared the transformation efficiencies of mutant NRAS and KRAS in immortal, non-transformed Ink4a/Arf-deficient melanocytes. NRAS mutation leads to increased cellular proliferation and is potently tumorigenic. In contrast, KRAS mutation does not enhance melanocyte proliferation and is only weakly tumorigenic on its own. While both NRAS and KRAS activate MAPK signaling, only NRAS enhances MYC activity in these cells. Our data suggests that the activity of specific RAS isoforms is context dependent and provides a possible explanation for the prevalence of NRAS mutations in melanoma.In addition, understanding this mechanism will have important implications for cancer therapies targeting RAS pathways. Keywords: RAS isoforms Overall design: Common Reference

INSTRUMENT(S): Van Andel Institute Mouse 15K cDNA Array - rel4

ORGANISM(S): Mus musculus  

SUBMITTER: Sheri Holmen   

PROVIDER: GSE6194 | GEO | 2006-10-30

SECONDARY ACCESSION(S): PRJNA100677

REPOSITORIES: GEO

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