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Gene expression profile of microglial cells under oxygen-glucose deprivation

ABSTRACT: Migroglia cells were exposed to oxygen-glucose deprivation (OGD) for 3 h. The mRNA was isolated and the expression profiles of OGD-activated cells were compared with the profiles of resting cells. Overall design: Two samples were analysed. mRNAs that were differentially expressed (increased or decreased in expression by ≥1.5-fold) between the OGD-activated and resting cells were identified.

INSTRUMENT(S): [Rat230_2] Affymetrix Rat Genome 230 2.0 Array

SUBMITTER: Peng Wang  

PROVIDER: GSE63505 | GEO | 2015-11-23



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MicroRNA-181c negatively regulates the inflammatory response in oxygen-glucose-deprived microglia by targeting Toll-like receptor 4.

Zhang Li L   Li Ya-Jian YJ   Wu Xun-Yi XY   Hong Zhen Z   Wei Wen-Shi WS  

Journal of neurochemistry 20150212 6

Cerebral hypoxia/ischemia rapidly induces inflammation in the brain, which is characterized by microglial activation and the release of inflammatory cytokines. We have previously demonstrated that miR-181c can directly regulate tumor necrosis factor (TNF)-α production post-transcriptionally. Here, we determined that hypoxia up-regulated TLR4 expression but down-regulated miR-181c expression in primary microglia. We also demonstrated that miR-181c suppresses TLR4 by directly binding its 3'-untran  ...[more]

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