Genomics

Dataset Information

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Purification and transcriptomic analysis of mouse fetal Leydig cells reveals candidate genes for disorders of sex development


ABSTRACT: To examine the transcriptome of early testicular somatic cells during gonadogenesis at 12.5dpc RNA sequencing (RNA-Seq) was performed on murine primary testicular cell lineages isolated from the Sf1-eGFP line by FACS. The three main somatic cell lineages of the testis were isolated: the Sertoli cells which direct male development; the fetal Leydig cells (FLCs) that produce steroid hormones and virilise the XY individual and a heterogenous population of interstitial cells, some of which give rise to the adult Leydig cells (ALCs). This dataset provides a platform for exploring the biology of FLCs and understanding the role of these cells in testicular development and masculinization of the embryo, and a basis for targeted studies designed to identify causes of idiopathic XY DSD.

ORGANISM(S): Mus musculus

PROVIDER: GSE65498 | GEO | 2015/05/21

SECONDARY ACCESSION(S): PRJNA274224

REPOSITORIES: GEO

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