Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents

ABSTRACT: Leydig cells (LCs) are the primary androgen producing cells in males throughout development and appear in chronologically distinct populations; fetal Leydig cells (FLCs), neonatal LCs and adult Leydig cells (ALCs). ALCs are responsible for progression through puberty and for maintenance of reproductive functions in adulthood. In patients with reproductive problems, such as infertility or testicular cancer, and especially in men with high gonadotrophin levels, LC function is often impaired, and LCs may cluster abnormally into hyperplastic micronodules. The purpose of this study was to investigate whether ALCs within hyperplastic micronodules display characteristics of FLCs. Transcriptome profiling was performed on LCs microdissected from 12 frozen human tissue samples, including morphologi

ORGANISM(S): Homo sapiens

SUBMITTER: Kirstine Belling 

PROVIDER: E-MTAB-5453 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress