Genomics

Dataset Information

42

Complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis


ABSTRACT: Using a deletion mutant lacking portions of the response regulator, MprA, and the histidine kinase, MprB, we demonstrated by DNA microarrays that MprAB activates sigE and sigB under SDS stress and during logarithmic growth. Keywords: effects of 0.05% SDS on Mtb gene expression Overall design: The expression of SigE-regulated genes {Manganelli, 2004 #212} was evaluated in SDS-treated and control cultures of H37Rv and Rv-D981, using array analyses, for each pair of samples in each experiment, dye flips were performed

INSTRUMENT(S): PHRI-UMNDJ Mycobacterium tuberculosis 4.8K CAG_Mtb

SUBMITTER: Saleena Ghanny  

PROVIDER: GSE6750 | GEO | 2007-03-28

SECONDARY ACCESSION(S): PRJNA98953

REPOSITORIES: GEO

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Publications

Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis.

Pang Xiuhua X   Vu Phong P   Byrd Thomas F TF   Ghanny Saleena S   Soteropoulos Patricia P   Mukamolova Galina V GV   Wu Shiping S   Samten Buka B   Howard Susan T ST  

Microbiology (Reading, England) 20070401 Pt 4


Two-component systems are important constituents of bacterial regulatory networks. Results of this investigation into the role of the MprAB two-component system of Mycobacterium tuberculosis indicate that it is associated with the regulation of several stress-responsive regulons. Using a deletion mutant lacking portions of the response regulator, MprA, and the histidine kinase, MprB, it was demonstrated by real-time PCR, primer extension analyses and DNA microarrays that MprAB activates sigma fa  ...[more]

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