Ontology highlight
ABSTRACT:
INSTRUMENT(S): PHRI-UMNDJ Mycobacterium tuberculosis 4.8K CAG_Mtb
SUBMITTER: Saleena Ghanny
PROVIDER: GSE6750 | GEO | 2007-03-28
SECONDARY ACCESSION(S): PRJNA98953
REPOSITORIES: GEO
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Pang Xiuhua X Vu Phong P Byrd Thomas F TF Ghanny Saleena S Soteropoulos Patricia P Mukamolova Galina V GV Wu Shiping S Samten Buka B Howard Susan T ST
Microbiology (Reading, England) 20070401 Pt 4
Two-component systems are important constituents of bacterial regulatory networks. Results of this investigation into the role of the MprAB two-component system of Mycobacterium tuberculosis indicate that it is associated with the regulation of several stress-responsive regulons. Using a deletion mutant lacking portions of the response regulator, MprA, and the histidine kinase, MprB, it was demonstrated by real-time PCR, primer extension analyses and DNA microarrays that MprAB activates sigma fa ...[more]